If you are to try this tweak, make sure you have vsync on. But generally speaking, the Fallout 4 crashes because of the video resolution, the graphics card issues or because of the hardware issues (ensure that your computer meets the minimum Disable any mods added and start a 'new' save to see if the issue occurs on a brand new game.
Randomly just crashes to the desktop, VATS doesn Some gamers said FO4 is crashing in the intro video only, while others said- it crashed even before the intro scene appears or during the gameplay.
It crashes many times when you try to install it on windows 7, 8 and 10.